The pathogenic capabilities of fifteen isolates of Botryodiplodia theobromae Pat. Isolated from nine hosts (Mango, Grapevine, Apple, Apricot, Plum, Peach, Pear, Persimmon and Palm) at various region of Egypt were studied on date palm off-shoot. All isolates were pathogenic on date palm off-shoot except the Mango isolates. Seven days after inoculating date palm off-shoots (Zaghloul cv.), with grapevine isolate the fungal hyphae were clearly noticed in parenchyma cells and spread towards phloem, xylem parenchyma and protoxylem causing necrosis. After 14 days from inoculation, the fungal hyphae completely colonized the meta-xylem. The linear growth of S. theobromae was completely inhibited at 10 ppm of Thiophanate-methyl (Hista 70% w.p) and Carbendazim (Actazime 50% w.p) followed by Pyrifenox (Dorado 200 E.c) at 40 porn. and Propioconazol as Cornazol 10 Ec) at 50 ppm. Carbendazim and Thiophanat-methyl gave the best control followed by Propioconazol and Pyrifenox.