This study was carried out to investigate the ability of minimum level (0.5%) (Tri star, Mycoband and Mould Stop Super) to resist the toxicity of Ochratoxin A (7mg 0.A/ Kg diet). The growth parameters and protein fractionation in Oreochromis nlloticus and Cyprinus carpio were recorded. Five groups of apparently healthy fish with mean body weight of 50-60 g for Oreochromis niloticus^-, and fingerlings with a mean body weight of 9-11 g for Cyprinus carpio were used. Ochratoxin A caused loss in live body weight gains in Oreochromis niloticus and Cyprinus carpio. Addition of the adsorbents reduced the had effects of Ochratoxin A on growth performance (Live body weight, body weight gain and specific growth rate). Concurred the electrophoretic investigation, plasma protein of fish showed the presence of 22-24 and 18 main fractions in control group of the various sera of Oreochromis niloticus and Cyprinus carpi°, respectively. The genotoxic effects of ochratoxin A led to a loss of two bands at mobility 0.01 & 0.135, while, new fraction appeared at mobility 0.96 in Orcochromis nilottus. Also, new fractions appeared at mobility 0.059, 0.089, 0.774 & 0.904 in Cyprinus carpi°. Addition of 0.5% adsorbents (Tri star, mycoband and Mould Stop Super) on contaminated diet with 7 mg ochratoxin A /kg led to appearance of new bands at mobility 0.01, 0.135 & 0.539 in 0. niloticus, and at mobility 0.281 & 0.824 in Cyprinus carpio as control group. It is concluded that the adsorbents were able to resist the toxicity of Ochratoxin A and to improve the growth parameters and plasma protein in fish.