Nigella Saliva was used as diet supplementation in group of mice experimentally infected with Salmonella Typhimurium. It was found that mice that took diet with Nigella Sativa and experimentally infected with Salmonella Typhimurium showed improving in body weight and survival ratio was 96% compared with the group that had diet without Nigella Sativa and was experimentally infected with Salmonella Typhimurium. Bacteriological examination revealed that mice of treated group showed no histopathological changes and regained their normal appearance, while those of non-treated group showed infiltration of liver with mature and premature leucocytic cells in the hepatic tissues, the heart showed leucocytic inflammatory cells infiltration in between the vascular degenerated myocardial bundles. Finally, Nigella Sativa can be used in enhancing the immune system as well as it improved the growth rate performance.