Two experiments were conducted during 2019/20 and 2020/21 winter seasons at Nubariah Research Station, El-Behyra governorate affiliated with Agricultural Research Center, Egypt. The study aimed to identify the effect of three wheat sowing methods i.e. drill, broadcasting and drill on raised beds (RB) and six weed control treatments i.e. “MCPA35%-Florasulam1%" at rate 595cm³/ha (Trigos), Clodinafop-propargyl15% at rate 333g/ha (Hock), Carfentrazone-ethyl40% at rate 36g/ha (Value), “MCPA35%-Florasulam1%" at rate 595cm³/ha (Trigos)+Clodinafop-propargyl15% at rate 333g/ha (Hock), Hand weeding once and untreated check on wheat growth characteristics and yields. A split-plot design with three replications was used. The results showed that the drill sowing method was the best in reducing the infestation of weed species by (35.6 and 17.2% in 2019/20 and 2020/21 seasons, respectively) compared to raised beds method, which was reflected in producing the highest values of grain and straw yields of wheat compared to broadcasting and raised beds sowing methods, under the high infestation rate of weeds (21.4 ton and 13.3 ton fresh weight per hectare in 2019/20 and 2020/21 seasons, respectively). The superior weed control treatment for reducing weed species and increasing both grain and straw yields of wheat was Trigos at rate 595cm³/ha+ Hock at rate 333g/ha followed by Hand weeding, Value at rate 36g/ha and Trigos at rate 595cm³/ha. The interactions between the drill and/or drill on raised beds sowing methods with the four previous weed control treatments gave the highest reduce in the annual weed species, highest grain and straw yields and gave the highest economic values.