Gimmizah (G) and Dolckl-4 (04) hens of 48 weeks of age were fed diets with two levels of allatodn (AFB,) 2 and 5 ppm without or with Mycodote by level of 0.1% for three weeks. The dinical and histopathological changes In some organs and glands as affected by treatment were studied. The results obtained could be summarized as follow: 1- Clinical changes Liver, kidney, spleen and heart weight as a percentage of live body weight of (G) and (D4) hens were significantly (P<0.05) increased during the treatment period, While weight of bursa of fabridus and thymus % of live body weight decreased significantly in the treated groups compared to the control group. 2- Histopathological changes Birds fed afiatoxicated diets by S ppm without Mycodote showed focal aggregation of lymphoid cells In the hepatic tissues associated with dilatation in the portal vein. The Kupffer cells were proliferated In diffuse manner allover the hepatic tissue. Also, the group fed afiatoxificated (Sppm) plus antitoxin (0.01% Mycodote) showed mononuclear leucocytes inflammatory cells infiltration in the portal area. The kidney of birds fed 5ppm aflatoxin in the diet showed that there was focal extravasation of red blood cells in between the renal tubules, while, those fed Sppm aflatoxin plus 0.01% Mycodote, focal aggregation of lymphiod cells was observed In between the degenerated renal tubules.