The effect of  ¼  LD₅₀ (23.15 mg/kg b.w.) oral administration of ethanolic Oshar leaves extract for 2, 4, 6 and 8 days on body weight and hematological parameters of Norway rat Rattus norvegicus induding Red blood cell R. B. Cs, white blood cell W. B. Cs and hemoglobin were investigated. The Oshar extract caused a significant decrease in body weight and a significantly increase in white blood cell W. B .Cs,•while red blood cells R. B. Cs and hemoglobin significantly decrea;ed Histological changes of kidney were shown in the form of Hyperemia in the glomerulars tuft of the glomeruli and intertubular blood vessels. While Focal extravasabon of red blood cells R. B. Cs and hemosiderin pigments between the degenerated renal tubules at the Corticomedullary junction, Inaddition Mononuclear leucocytes inflammatory cells infiltration in the perivascular area surrounding the diluted blood vessels in between the degenerated renal tubules at the cortex. However, it was found that the use of sublethal doses of ethanolic Oshar leaves extract has greatly affected the blood picture and kidney tissue of rats.