The biochemical effects of the two natural products i.e. Neernlx 4.5% (plant extract) and Vertemic 1.8% (biocide abamectin) were studied on the brown garden snail Eobania vennitukta Muller Animals were treated with sub-lethal concentration (¹/₄ LC93) of each tested compound using contact (thin film) technique. Some enzymes activities i. e. liver enzymes, aspartate aminobansferase (AST), alanine aminotransferase (ALT), total protein and total lipid were determined. Also, respiratory enzymes (peroxidase and catalase) were measured after 1, 2, 3 and 4 days post-treatment. Results showed that the two tested compounds reduced the activity of AST gradually with the progression of periods after treatment while the contrary occurred with ALT as both compounds enhanced its activity proportionally than control Regarding total lipid, both compound had the same effects as they raised total lipid percentage while their effect differed on total protein specially in the third and fourth days of treatment whereas Neemix induced a markedly reduction in total protein percentage comparatively with increase in case of Vertemic. Concerning peroxidase enzyme, its activity decreased gradually with the elongation of the period after treatment for the two tested compounds. Catalase enzyme took adverse way as its activity increased in the 1^g, 2". 3n¹ days, then it decreased in the 4¹" day for both compounds. Generally, Neendx compound was more effective than Vertemic against E. vermiadata.