Effect of two natural compounds; Neemix 4.5% (plant extract) and Vertimic 1.8% bio compound (abamectin) in addition to the molluscicide compound Cekumeta 5.0% (metaldhyd) were evaluated as a bait or contact (thin film) against two land snail species, Monody obstructa and Eobania vermlculata under laboratory and field conditions of Kafr El —Sheikh Governorate. Laboratory results showed that when the three tested compounds used as a bait, Cekumeta was the most toxic one against the two snail species followed by Vertimic, while Neemix was the lowest effective one. On the other hand, M. obstructa was more susceptible for Neemix and Vertimic than E. yermiculata while vice- versa occurred in case of Cekumeta bait compound. In case of contact method, Neemix compound was more toxic to Eobania E. vermiculata. than M. obstructs. In contrast M. obstructa was more sensitive to Vertimic than Evora/rat/ate. The field results were in harmony with those which were obtained from laboratory as Cekumeta molluscicide bait was the most efficient one against both species followed with Vertimic and Neemix when applied as baits. But when applied as a spray, Neemix was more efficacy than Vertimic. Also, At obstructa was more susceptible to both compounds than E yermicvlata.