Spinosad, a new biochemical product was evaluated beside the known biological agents: Bacillus thuringiensis and the Granulosis virus in comparison with the chemical insecticide Tilton of the Organophosphorus group against the Potato Tuber Moth, Phthorimaea operculella (Zeller) in stores. Spinosad treatments showed high efficiency against the PTM infestations in both tested concentrations (0.125 and 0.062) over other tested control measures. Spinosad also, performed very long persistence through the whole storing period. The chemical insecticide followed after Spinosad but its efficiency start to collapse after the third inspection. Both of virus treatments (Virotecto and the GV infected larvae) give similar results in controlling the PTM. The bacterial treatment came in the fourth rank after the viral treatments. The highest PTM infestation were recorded for the control treatment.