The population density of seychelles fluted scale, Icerya seyche//arum was studied in relation with the toughness and anatomical characteristics of the leaves of five mango cultivars. The order of susceptibility levels of mango cultivars to I. seychellarum could be arranged in descending order as follows: Sultani (highly susceptible) > Baladi > liendi > Ewaisi >Alphonso (completely resistant). Ewaisi leaves were characterized by higher stomata density, thicker blade, as well as thicker upper and lower epidermis than those of the other studied mango cultivars. Lignin and tannins were deposited mainly in the palisade cells, phloem, pericyclic fibers, and in some cortical parenchyma cells of both Ewaisi and Alphonso leaves. Leaves of the completely resistant cultivar (Alphonse) were characterized by heavily lignified epidermis cells. In consequence, leaves of Ewaisi and Alphonse cultivars had higher toughness than the other studied mango cultivars. The overall results suggest that of the studied leaf properties, heavily lignified tissues and high contents of condensed tannins play an important role in resistance of Ewaisi and Alphonse culuvars to I. seychellarum infestation.