The perennial weeds under study i.e. cogongrass "Imperata cyfindrica (L) p.", bermudagrass "Cynthia; dactylon (L) pers.", nutsedge "Cypenis rotundas L." and field bindweed " Oonvolvulus arvensis L." are cnsidered to be the dominant noxious weeds in most parts of the world. All treatments gave significant effect on controlling the perennial weeds mixture mentioned above. Glyphosate (Roundup 48 %) at 4.0 Vied. either used once or twice was the superior herbicide for controlling the perennial weeds .That was true in the four surveys at 3, 6, 9 and 12 weeks and in both seasons, this may be due to the fact that this herbicide has a non­selective effect and translacte effectively in the growing part of annual and perennial weeds. According to the reduction of the perennial weeds population estimated by visual assessment and the number/m², the treatments could be arrangeed in the a descending order: Roundup at 4.0 Vfed. used twice and once, Fusilade Super at 2.0 V fed used twice and once, mulching by banana leaves, hand hoeing at four times and the lowest reduction was the cutting at three times in the four surveys in the first season, Roundup at 4.0 I/fed. used twice and once, hand hoeing four times, Fusilade Super used 2.0 V fed used twice, mulching by leaves, Fusilade Super at 2.0 V fed used once and the lowest was the cutting three limes, compared to un treated control in the four surveys in the second season.Another study, was conducted to estimate the predictive equations between the effective dose of glyphosate (Herbazid) and killing percent of the above four perennial weeds. The best control percent was done by using 4 Vied. Concentration of four weed under study.