Systemic acquired resistance in cotton plants against infection with Fusarium oxysporum f.sp. vasinfectum (Atk) snyd. And Hank), (FOV) was expressed when cotton seeds of genotype Giza 80 X Australian genotype 19199 were soaked in solutions of various resistance elicitors (REs). All REs, Ascorbic add (AA), benzoic acid (BA), benzothiadiazole (BTH), citric acid (CA), cinnamic acid (CiA), hydroquinone (HQ), salicylic add (SA), sodium citrate (NaC), sodium metbisulfate (NaMS) and thiourea (THU) induced resistance that increased with increasing REs concentrations. BTH was the most efficient elicitor in inducing resistance in cotton plants. Efficiency of BTH was highly affected by the concentration and by cotton genotype. The most susceptible cotton genotype Giza 80 X Australian genotype 19199 showed the highest response to the application of BTH at all concentrations. A significant positive correlation was observed between susceptibility of cotton genotypes to FOV infection and efficiency of BTH in inducing resistance. In other words, susceptibility of the genotype positively correlated with the magnitude of response to the elicitor. Thus, infection accounted for 73 and 64 % of the total variation in BTH efficiency when it was applied at 50 and 100 ppm, respectively.