Two hundreds and eighty four field cases of diseased rabbits either living ailing (135) or dead (149) were examined for the presence of bacterial infections. Most of the examined rabbits showed polybacterial infections. Pasteureila multocida, E.coli, Eionietella bronchiseptica, Kiebsiella pneumoniae, Staphylococcus aureus, Salmonella typhimurium and Pseudomonas aeruginosa were isolated from the examined samples in the ratios of 38.98%, 24.92% ,16.61%, 10.54%, 5.11%, 1.92% and 1.92%, respectively. E.coli isolates were serotyped as 02 , 078, 0119, 0114 and untypable which all found to be rhamnose negative. Pathoginicity tests of the isolated bacterial agents were studied . Symptoms, mortality rates and postmortem lesions were recorded and discussed in details. Antibiogram of the isolated bacterial species revealed serotypic variation in drug sensitivity to various antibiotics. Fluoroquinolones antibiotics were shown to be the most effective followed by chloramphenicol, sulphamethoxalin­trimethoprim and gentamycin. Fluoroquinolone are potentially good treatment for most bacterial infections in rabbits.