All possible mating among four F2 selections of the highest lint percentage and four F2 selections of the highest seed index were made for three populations (G. 45 x G. 75 (I), G. 87 x G. 89 (II) and G. 86 (III) grown from open-pollinated bulks for four years) to produce desirable recombinations. The 28-hybrids resulted from each population gave the highest means of lint yield/plant, bolls/plant and seeds/boll compared with the means of the better parent for populations I and II. In addition, the 28 hybrids means performance were higher than Giza 86 pure line mean for lint/seed, lint percentage and seed index in population III. The highest predicted genetic advance was achieved for lint yield/plant, bolls/plant, lint/seed and seed index in the three populations. High to low genetic advances were found to associated with high to low values of GCA most studied characters in the three populations.