The relative susceptibility and monitoring of nine widely spread grapevine local and established foreign varieties, 8anaty "white Thompson seedless", Flame "red seedless", Superior, Red Romi, Balady, Bez El-Ante, Fayoumi, King Robby and Kremson to the wasp beetle, Chlorophorus varius (Coleoptera: Cerambyddae) borer infestation as well as the population fluctuation were studied at Giza govemorate, during the three successive years 2004, 2005 and 2006. The mean rate and degree of susceptibility of grapevine varieties to C varius infestation reached 22.5% infestation and 5.2 holes / tree, respectively. According to different varieties, the commencement dates of C varius flight varied according to varieties from early April to early May until stopped in late September, October or November. Mostly there were two peaks of beetles activities during June / July and July, August or September. Summer months recorded the maximum flight (0.06-1.67 beetles), followed by spring (0.02-0.85 beetles), then autumn (0.01-0.30 beetle) /tree, and stopped during winter. The total numbers of beetles per year ranged from 0.09 to 2.55 beetles /tree. Mostly, it had one or two brood and the beetles' activity lasted 4 to 8 months according to varieties. Infestation was almost doubled during only one year, but 3.2 times dung two year. This is a serious parameter that imposes urgent need of controlling the pest in vineyards yearly. Effect of weather factors on the borers activity was mostly positively significant with day maximum, day minimum, and day mean temperatures but negatively and insignificantly with day mean relative humidity.