Screening some epiphytic microorganisms isolated from the phyllosphere of sugar beet plants for their potential antagonism against Cercospora beticola revealed a high potency of one isolate of each of Pseudomonas fluorescens, P.aureginosa, Bacillus subtilis, Streptomyces albidoflavus, S.lavandulae and S. griseoviridis. One isolate of P.putida showed moderate inhibitory effect. Among fungi, one isolate of Trichoderma harzianum exhibited moderate inhibitory activity. Some isolates were weak inhibitors. Isolates were evaluated for their ability to elaborate secondary metabolites, such as HCN, IAA, siderophores, and some hydrolytic enzymes such as chitinase, lipase, pectinase, protease and cellulose.