A field experiment was conducted in Ali Moubarak Experimental Farm at El-Bostan Reclaimed Soil Sector (100 km northwest of Cairo). The soil was none saline sandy soil irrigated with sprinkler system. The aim was to study the efficiency of application of town refuse compost, urea (46 % N) individually and in combination on wheat production along with the uptake of the nutrients N, P, K, Fe, Mn and Zn. The used rates were 0,2 and 4 ton compost and 0, 23 and 46 kg N as urea /fed. The obtained results could be summarized as follows: The application of compost at a rate of 4 ton compost/fed increased significantly grain uptake of both P and Zn, straw yield, straw uptake of Fe and Mn; and total uptake of N, Fe and Mn . At the rate of 2 ton compost/fed it significantly increased only straw and total uptake of Mn compared to the control . Urea application at the rate of 46 kg N/fed was significantly increased grain yield , grain uptake of N and P and total P uptake, while the rate of 23 kg N/fed increased significantly grain N . The combination of compost and urea caused significant increases in most of the studied parameters; proportionally correlated with increasing their rates of application. The treatment of 4 ton compost/fed combined with 46 kg N/fed as urea was significantly higher in grain yield, grain uptake of N, P, K, Mn and Zn, straw yield, straw uptake of N, P, K, Fe and Mn over the control. This treatment was the highest treatment in grain yield, grain N, P, Mn and straw Mn compared to the other treatments.