The tetranychid mite is considered one of the important mite pests attacking cotton plants in Egypt. The present work was carried out to study the efficacy of the tested compounds against the two-spotted spider mite, Tetranychus urticae under field conditions. First season (2005): The cotton plants were sprayed by using the recommended concentration of seven compounds, namely (agrin, Vertemic, hexaflumuron, Super Misrona Oil, Micronized Sulfur, and Liquid Sulfur) to study the effectiveness on the adult stages of the two-spotted spider mite, Tetranychus urticae. Vertemic gave highly reduction percent (85.11%) in infestation against the adult stages of T. urticae, while Agrin, flufenoxuron, hexaflumuron, Super Misrona Oil, Micronized Sulfur, and Liquid Sulfur gave approximately similar results 66.20, 77.10, 72.16, 70.96, 71.73 and 70.29, respectively. Second season (2006): Vertemic gave highly percent reduction (88.32%) in infestation against the adult stages of T. urticae, while, agrin, flufenoxuron, hexaflumuron, Super Misrona Oil, Micronized Sulfur, and Liquid Sulfur gave approximately similar results 69.17, 83.67, 75.71, 75.10, 69.15 and 72.02, respectively.