Aloe extract was used as diet supplementation in a group of rats experimentally infected with Salmonella typhimurium. It was found that rats that fed on diet with aloes extract for 30 days, then, experimentally infected with Salmonella typhimurium showed survival rate 92% in comparison with group of rats fed on ration without aloes extract and experimentally infected with Salmonella typhimurium. Histopathological examination revealed that treated group with rats of aloes extract showed few histopathological changes, while those non-treated group showed significant infiltration of liver with mature and premature leucocytic cells in hepatic tissues with severe necrotic changes. Moreover, the heart of such untreated group with aloes extract showed leucocytic inflammatory cells infiltration between the bundles of degenerated cardiac muscles.