Two field experiments were carried out at Sids Agricultural Research station, Beni-suef Governumberrate in 2008 and 2009 seasons, to study the response of growth, fruiting and yield of the Egyptian cotton cultivar Giza 80 (G. barbadense L.) to organic manure (sheep manures) alone or combined with mineral nitrogen fertilizer and foliar application with Kinetin and Gebirline GA3. The treatment included the control treatment, one concentration of each of kinetin (5 ppm) and GA3 (100 ppm) which sprayed at the squaring stage obtained could be summarized as follows: The combined application of 30 kg N / fed. as sheep manures a long with 30 kg mineral N / fed. as ammonium nitrate significantly increased plant height, Number of fruiting branches / plant, Number of open bolls / plant, boll weight in the form of seed cotton yield (feddan), seed index and chemical composition of leaf as compared with the control. (ammonium nitrate)in both seasons. Generally, the application of sheep manures at rate of 30 kg N / fed combined with 30 kg N / fed. (ammonium nitrate) and sprayed by Kinetin gave the highest cotton yield and yield components in both seasons. The studied treatments had insignificant effect on earliness % and fiber quality in both seasons.