The hibiscus mealybug, Maconellicoccus hirsutus (Green) (Hemiptera: Pseudococcidae) is an important pest on grapevine, guava, soybean, peanut and other plants in various locations in Egypt. In addition to debilitating the host plant due to the loss of sap, the resulting honeydew becomes covered in a thick mat of sooty mould, severely reducing respiration and photosynthesis. This paper presents the results of laboratory and field tests on the effect of natural compounds (Biofly and NeemAzal) and the formulated compounds (Super Mesrona oil and Sumithion) on M. hirsutus and its parasitoids and predators. The laboratory tests indicated that the effect of Sumithion on the mealybug and its natural enemies ranged from 58-98%, Biofly from 15-80%, Super Mesrona oil from 24-98% and NeemAzal from 17-73%, respectively. For the field tests the results indicated that Biofly gave moderate results against nymphs of M. hirsutus, with mean mortality for the two years of 41 & 36% after 3 days, 55 & 51% after 7 days and 58 & 53% after 15 days, while the parasitoids Anagyrus kamali and A. pseudococci (Hymenoptera: Encyrtidae) and Allotropa mecrida (Hymenoptera: Platygastridae) had mortalities of 61 & 48%, 66 & 59%, 55 & 47% respectively for the same periods in the 2 years. The predators Scymnus seriacus (Coleoptera: Coccinellidae) had 50 & 37% mortality and Chrysopa vulgaris aegyptica (Neuroptera: Chrysopidae) had 53 & 41% mortality after 15 days respectively. On the other hand, Sumithion had high efficacy against nymphs of M. hirsutus, with percent reductions of 95%, 96% and 91% for 2008 and 91%, 93% and 88% for 2009. The parasitoids A. kamali, A. pseudococci and A. mecrida had mortalities of 95 & 93%, 90 & 87% and 93 & 90% respectively after 15 days in the two years, while the predators, Scymnus seriacus and Chrysopa vulgaris aegyptica had percent reductions of 88 & 84% and 85 & 82% after 15 days in the 2 years.