Antifeedant, growth inhibtory and toxicity effects of chlorantraniliprole, thiamethoxam and novaluron formulations at 1,1/2 and 1/4 field recommended rates were tested against the cotton leafworm S. littoralis, during the cotton seasons of 2011 and 2012. Results showed that, feeding the 4th instar larvae on treated cotton leaves at different rates decreased the food consumption. Morever, chlorantraniliprole seemes to be the most powerfull tested compounds. Feeding detrrence index for chlorantraniliprole, thiamethoxam and novaluron against 4th instar Spodoptera larvae were 92.5, 51.4 and 71.9 %, respectively after one day expoure, at low rats (¼ field rate) during 2011 cotton season. While, Feeding detrrence index were 92.0, 78.7 and 76.9 %, respectively during 2012 cotton seasonThe relative growth rate of 4th instar Spodoptera larvae fed on cotton leaves treated with chlorantraniliprole, thiamethoxam and novaluron at 1, ½ and ¼ field rates was decreased. Toxicity of chlorantraniliprole, thiamethoxam and novaluron formulations was recorded clearly after two days expoure. After three days expoure, chlorantraniliprole gives 97.5, 95.5 and 95.0 percent mortality at 1, ½ and ¼ field rates, respectively against 4th instar Spodoptera larvae during 2011 cotton season. Thiamethoxam gives 77.5, 67.5 and 60.0 percent mortality at 1, ½ and ¼ field rates, respectively, while novaluron gives 62.5, 70.0 and 60.0 percent mortality, respectively. During 2012 cotton season, chlorantraniliprole gives 95.0, 95.0 and 92.5 percent mortality at 1, ½ and ¼ field rates, respectively, while thiamethoxam gives 90.0, 95.0 and 87.5 percent mortality, respectively. Novaluron gave 97.5 percent mortality for all field rates