Toxicity of chlorpyrifos-methyl, methomyl, chlorantraniliprole, thiamethoxam and novaluron at two low concentrations (1/2 & 1/4 field recommended rates) and their binary mixtures were tested against 4th instar of Spodoptera littoralis larvae at two cotton growing seasons 2011 and 2012. Percent mortality of chlorpyrifosmethyl, methomyl, chlorantraniliprole, thiamethoxam and novaluron at 1/2 field rates on 2011 cotton season, was 22.5, 27.5, 17.5, 12.5 and 12.5%, respectively after 24 hours, while it was 72.5, 52.5, 90.0, 57.5 and 57.5%, respectively after 48 hours. Percent mortality at 1/4 field rates, was 17.5, 17.5, 22.5, 2.5 and 27.5%, respectively after 24 hours, while it was 42.5, 30.0, 85.0, 50.0 and 50.0%, respectively after 48 hours. Concerning mortality percentage of chlorpyrifos-methyl, methomyl, chlorantraniliprole, thiamethoxam and novaluron at 1/2 field rates on 2012 cotton season, was 32.5, 32.5, 27.5, 20.0 and 20.0%, respectively after 24 hours, while it was 72.5, 70.0, 50.0, 57.5 and 62.5%, respectively after 48 hours. Percent mortality at 1/4 field rates, was 27.5, 27.5, 20.0, 12.5 and 30.0%, respectively after 24 hours, while it was 67.5, 50.0, 52.5, 40.0 and 62.5%, respectively after 48 hoursDuring 2011 cotton season, all tested insecticide mixtures have antagonistic effects (cotoxicity factors < 0) after 24 and 48 hours, except for chlorpyrifos-methyl (1/2 F.R)/chlorantraniliprole (1/2 F.R) mixture, chlorpyrifos-methyl (1/2 F.R)/thiamethoxam (1/2 F.R) mixture and chlorpyrifos-methyl (1/4 F.R)/chlorantraniliprole (1/2 F.R) mixture exhibited potentiation effects (cotoxicity factors were +6.3, +7.1 and +7.1, respectively), after 24 hours. Methomyl (1/4 F.R)/thiamethoxam (1/4 F.R) mixture exhibited potentiation effects (cotoxicity factors was 12.5), while methomyl (1/4 F.R)/novaluron (1/2 F.R) mixture exhibited additive effects (cotoxicity factors was 0). At 2012 cotton season, after 24 hours, only one [chlorpyrifosmethyl (1/2 F.R)/chlorantraniliprole (1/4 F.R) mixture] of 24 binary mixture tested showed potentiation effect. While the majority, 22 mixtures exhibited antagonistic effects, and only one exhibited additive effects [chlorpyrifos-methyl (1/2 F.R)/chlorantraniliprole (1/2 F.R) mixture]. After 48 hours, all tested insecticides mixtures have antagonistic effect