The efficiency of two novel compounds (takumi and radiant) and conventional insecticide (methomyl) against the fourth instar larvae of Agrotis ipsilon was evaluated under laboratory conditions through determination their LC50 values. Takumi was the most toxic one against the 4th larvae treated by both feeding and dipping techniques showing LC50s of 6 and 80 ppm, respectively. While, Radiant was the second one, the LC50s were 28 and 500 ppm, respectively. Whereas, methomyl was the least one, its LC50s were 187.5 and 900ppm, respectively. All the treated larvae were biologically affected by the three tested compounds. The effects were varied according to the applied method and compound. The larval treatments via leaf dip method had the highest effect in larval and pupal duration increase.Methomyl treatment induced the longest period in this respect, followed by takumi and radiant ones. Therefore, the treated larvae by this method were resulted in pupal malformation percent increase. While, the larval treatment via dip method had the strongest effect in shifting of sex ratio of males and females percent, decrease of pupation percent, pupal weight and adult longevity and increase of adult malformation percent. Also, the larval treatment of 4th instars with takumi by both leaf and larval dip and the treatment with radiant via larval dip method had the strongest effect in adult fecundity reduction to reach zero, as compared to591.6 and 524.9 eggs/female of control of both methods, respectively.