Experiments were carried out at Zagazig district, Sharqia Governorate during two successive seasons, 2007 & 2008 to evaluate the toxicity of some insecticides against S. littoralis larvae infesting cotton cultivations and some associated common predators. Chlorpyrifos and methoxyfenozide were the most potent insecticide in both initial and residual effect that caused highly significant reduction in the infestation rates of the pest as compared to other treatments at the initial and residual effects that recorded (98.21±0.783, 82.55±2.444%) as initial effect and (93.34±2.599, 85.32±2.195%) as residual effect during 2007 while during 2008 season it recorded (96.01±.0.723, 83.97±3.462%) and (89.89±2.715, 86.34±3.398 %) for initial and residual effect, respectively. Considering the initial and residual effects of the rest treatments, it could be arranged descendingly as teflubenzuron, tebufenozide, Tracer and finally Dipel 2X at both tested seasons. Chlorpyrifos and methoxyfenozide were the most toxic insecticides causing the highest significant reduction in the predator numbers that recorded (79.81±3.544, 24.73±2.162%) and (66.81±5.418, 29.36±3.468%) at 2007 and (71.60±3.84, 23.50±1.799%) and (64.91±3.569, 26.78±3.548) at 2008 in the initial and residual effects, respectively. Followed by Tracer, teflubenzuron, tebufenozide and Dipel 2X during the two successive seasons