Field and laboratory studies were carried out during two successive summer seasons in order to study the susceptibility of the different tested cantaloupe cultivars namely (Ideal, E81-065, Mirella ,Vicar, E81-013 and Magenta) to infestation by Thrips tabaci, Bemisia tabaci and Tetranychus urticae. Field studies were carried out during the two consecutive growing seasons (2006 and 2007). There were significant differences in the susceptibility of cantaloupe cultivars to infestation by these pests. These mentioned that, E81-065 and Magenta cultivars were the lowest infested ones by these pests. On the other hand, Mirella variety was the highest infested cultivar. To give a spot light on the reason of the differences in the susceptibility of the tested cantaloupe cultivars, chemical analysis of the dried leaves were carried out during growing season of 2007. Chemical analysis of infested leaves showed correlation between certain phytochemical components (organic and inorganic compounds); reduced, non-reduced and total sugars, potassium, total protein, carbohydrate, and phosphorous as well as moisture content and population density of T. tabaci, B. tabaci and T. urticae.