The objective of the present work was to compare the field efficiency of seven tested pesticides, Acarone 72% EC (Profenofos), Selecron 72% EC (Profenofos), Sumithion 50% EC (Fenitrothion), Diazonixy 60% EC (Diazinon), Chinook 35% SC (Imidacloprid), Vertimec 1.8% EC (Avermectin) and Actara 25% WG (Thiamethoxam), against larvae of the sugar beet fly, Pegomyia mixta on planting sugar beet in Sharkia Governorate during 2008/2009 and 2009/2010 sugar beet growing seasons. Data obtained revealed that Acarone (72% EC) gave the highest initial reduction in insect population (58.95%), followed by Diazonixy (56.68%). Selecron (72% EC) was the lowest effective (51.43%) in the first season, while in the second season, Acarone (72% EC), Selecron (72% EC) and Sumithion (50% EC) achieved excellent control against P. mixta. Reduction percentages were 90.37, 90.13 and 88.16% after one day of spraying (initial kill). Acarone (72% EC) increased the percentage of sugar content comparing with the other treatments, whereas, there were no differences between Sumithion (50% EC) and Control. The highest purity percentage was obtained from Selecron (72% EC) and Sumithion (50% EC) treatments (90.76 % and 89.33 % respectively) in the first season, while in the second season, Acarone (72% EC) and Vertimec (1.8% EC) increased the percentage of sugar content comparing with the other treatments, (19.70 % and 19.40 %). While, Selecron (72% EC) and control decreased those percentages of sugar (16.10 % and 14.70%). Selecron (72% EC) and Actara (25% WG) were increased purity percentage (94.71 % and 92.84 % respectively). Keywords: Pegomyia mixta, Pesticides, Profenofos, Fenitrothion, Diazinon, Imidacloprid, Avermectin, Thiamethoxam, Root yield and Sugar yield.