Insecticidal activities of four compounds namely Profenofos, Esfenvalirate, Flufenoxuron and Spinosad were evaluated either separately or in mixture with fungicides or IGRs against the 2nd instar larvae of the cotton leaf worm S.littoralis by using semi field bioassays technique throughout 2012 and 2013 seasons. The results indicate that mortality % of all tested insecticides at recommended rate alone at zero time after application was 87.75, 87.75, 85.71 and 93.87% larval mortality and residual effects after 15-days of treatments were 26.53, 22.44, 32.65 and 34.69 % larval mortality for profenofos, esfenvalirate, spinosad, and flufenoxuron respectively. Also, at half recommended rate at zero time mortality % was 51.02, 51.02, 53.03 and 51.02% larval mortality and residual effect reached 20.40, 12.24, 12.24 and 12.24 at 15-days after treatments with the same insecticides respectively. Interestingly, the same insecticides in combination with tested fungicides or insect growth regulator at half recommended rate were the most effective treatments giving excellent control and better results than that obtained by using full and half recommended rate alone against the 2nd instar larvae of S.littoralis throughout the two seasons. Fore, example, profenofos alone at half recommended rate at zero time interval caused 51.02 but recording 83.6, 95.91 and 91.83 % mortality when mixed with (difenoconazol, (penconazol) and (flufenoxuron) at half-recommended rate in the same period respectively. Also, esfenvalirate at half rate alone caused 51.02% mortality but recording 93.87, 91.83 and 89.75 % mortality when mixed with (difenoconazol) , (penconazol) and (flufenoxuron) at halfrecommended rate in the same period after treatment. Concerning, spinosad at half recommended rate alone at zero-time resulted in initial kill of 51.02% larval mortality, but caused 87.75, 91.83 and 93.87 % mortality when mixed with (difenoconazol), (penconazol) and (flufenoxuron) in the same period after treatment respectively. Moreover flufenoxuron alone gave 53.03 % mortality increased to 93.87, 93.87 % mortality when mixed with difenoconazol , penconazol, respectively. Generally, mixtures containing insecticides and EBI fungicides or IGRs at low rate were the most effective treatments of the tested insecticides giving excellent control and better results than that obtained by using full and half recommended rate of all compounds alone against the 2nd instar larvae of S.littoralis. It could be concluded that both EBI fungicides and IGR appeared promising in combination with insecticides as result of significant increasing its initial kill and residual effect.