The male antifertility compound: α-chlorohydrin (ACH) was tested for the control of Roof Rats, Rattus rattus. The compound was provided to rats as 1% ACH/crushed maize formulation for three successive days. The concentration and the period of application used were effective in producing permanent sterility in males. Two of the twelve tested males (16.6%) were died after two days. They ingested average daily amounts of ACH of reached 207.1 and 346.6 mg/kg body weight, respectively. The average daily amounts of ACH ingested by the ten surviving males over three successive days, ranged between 81.8 and 266.6 mg/kg. The microscopic examination of the testes and epididymides of rats sacrificed 7, 35 and 60 days after the application of ACH indicates that these organs were severely damaged and the process of spermatogenesis was greatly reduced. Most seminiferous tubules of examined testes were free of spermatozoa. In rats sacrificed after 60 days, most seminiferous tubules were atrophied and shrunk with extensive exfoliation of germ cells into the lumina of tubules. Epididymides of treated rats showed interstitial edema, and immature germ cells in the lumina of their ducts.