field and laboratory studies were carried out during two successive seasons (2012 and 2013) to study the susceptibility of seven cucumber cultivars (Fahd, PX 03648585, Bahi, CBA 911264 F1, Dora, CBA 910747 F1 and Nemsse) to infestation with Thrips tabaci (Lind.), Bemisia tabaci (Genn.), Aphis gossypii (Glover) and Tetranychus urticae (Koch). The results showed significant differences in the susceptibilities of the seven cultivars in both seasons. PX 03648585 cultivar was the most tolerant one to the infestation with the previous mentioned pests in both seasons while Bahi was the most susceptible one. Also, the determination of the content of some chemical components in the uninfested dry leaves of these cultivars was studied only for the summer season, 2013 to explain the differences in the susceptibilities of the tests cultivars. Studies showed significant positive correlation between the content of some chemical components and the different levels of infestations of the studied pests. The most susceptible cultivars, were positively correlated with high content of protein, carbohydrate, lipid and reducing sugar while the most tolerant one were contained mid or low amounts of these components.