field experiment was performed to evaluate whether using compost and natural rocks of phosphate and potassium with bio fertilizers could replace mineral fertilizers in potato production. The experiment was conducted at Giza Agriculture Research Station, Egypt. The potato tubers (Lady Rosetta and Lady Balfour cultivars) were planted during the third week of January 2016 and 2017 seasons. Individual or combined treatments of rock phosphate with phosphate dissolving bacteria (Bacillus megaterium) and feldspar with K releasing bacteria (Bacillus circulans) were applied in presence either mineral N or compost with N fixing bacteria (Azotobacter chroococcum + Azospirillium brasilense). The effects of these treatments on growth characteristics and yield component of potato were compared with recommended dose of NPK as mineral fertilizers. The results mentioned that Lady Balfour cultivar was significantly better in most vegetative traits and yield component than Lady Rosetta. All individual or combined treatments of rock phosphate and feldspar with mineral N did not show any significant differences in growth and yield characteristics compared to mineral NPK. All treatments of rock phosphate and feldspar with compost reduced the growth and yield characteristics compared to mineral NPK. The lowest reductions in yield were obtained by compost + rock phosphate and feldspar treatment. In general, rock phosphate and feldspar with phosphate dissolving bacteria and K releasing bacteria could be an alternative to mineral PK for similar yield and quality of potatoes as well as obtain the highest net return. Compost with N fixing bacteria could be a substitute for mineral N to produce a slightly lower yield of potatoes but it's distinguished by high quality and healthy.