field experiments were carried out in Etay Elbroud districts, El Behira governorate In summer plantation (mid July) sawing of maize plant throughout (2016/2017) seasons to study the efficacy of insect growth regulator (Nova) biopesticides (Absolute and Diple2x) and chemical pesticides (Jito, Coragen and Contradio) aguinst Spodoptera littoralis and on some accompanied predators (family coccinilidae). The results indicated that the percentage initial effect of the reduction of the tested compound of infestation for being (85.1, 77.2, 73.3, 52.7, 50.1 and 39.2%) in the first season (86.2, 73.7, 67.7, 60.00, 49.3 and 46.2%) in the second season for Jito, contrado, Nova, Coragen, Absolute and Diple2x respectively. The general mean of residual effect for Jito compound caused the servent effect recorded 88.7 and 88.55% as reduction percentage in both seasons 2016 and 2017, respectively. biopesticides recorded the least effect on predators being 26.6, 26.8 and 23.7% in the first season and also in the second season recorded 35.5 and 33.3% for Nova, Absolute and Diplex2 respectively while, the chemical pesticides Jito caused the highest mortality against predators.