influence of five-bed disinfectants known as (botanical mixture of Lawsonia inermis and Curcuma longa) Ankush(mixture of botanical and chemical), Amruth (botanical), FL (chemical mixture of formaldehyde and lime) and Vijatha (chemical) on some biochemical changes in the silkworms; Bombyx mori L.infected with Beauveria bassiana (Bals) Vuill was evaluated in the present study. The results showed that, infection of B. mori with B. bassiana reduced the total proteins, carbohydrates and lipids contents in haemolymph compared to the normal control and decreased the activity of the three carbohydrates hydrolyzing enzymes (Trehalase, amylase and invertase). Application of the five disinfectants to the infected silkworm, B. mori increased total proteins, carbohydrates and lipids contents as compared to the infected control (the inoculated control). All disinfectants were decreased the activity of the three carbohydrates hydrolyzing enzymes compared to the inoculated control except the disinfectant LC which increased trehalase enzyme activity and the disinfectant FL increased the amylase and invertase activities. According to these results, it could be concluded that, the use of the disinfectants caused elevation the total proteins, carbohydrates and lipids contents and this elevation support the defense of B. mori against fungi and reducing the disease development.