In the current study, two equipment were used to control wheat Aphid, Rhopalosiphum padi. The first equipment, Knapsack sprayer (3WDB) with battery charge and flat fan nozzle. The second equipment, Knapsack motor sprayer (IE34F) with hydraulic pump and spray gun at New Salhyia city, Sharqia Governorate. The present study aimed to determine the effects of application method on initial and late biological efficacy of imidacloprid and dinotefuran (belong to neonicotinoid) against wheat aphid. Results in two seasons (2016 & 2017) indicated that, IE34F Motor sprayer (as high volume sprayer) showed less initial efficacy compared with 3WDB Power sprayer (as medium sprayer volume). Although the imidacloprid pesticide gives high efficacy compared with dinotefuran pesticide. The main obtained difference was Imidacloprid with 3WDB Power sprayer gave the highest efficacy with a significant difference compared with dinotefuran with IE34F Motor sprayer.