an experiment was conducted to study the effect of different herbicides, for weed control in wheat fields, during 2014- 2015, at the Arid Zone Research Farm, D. I. Khan, Pakistan. The treatments; including control (T1), Buctril Super (T2), Bromoxynil (T3), Austrian-M (T4), Segal (T5) and Dormic (T6); were arranged in Randomized Complete Block Design (RCB) with three replications. The grain yield and yield components data of wheat indicated that all the treatments of herbicides effectively control weeds and provide a better environment for the growth of crop that ultimately increased wheat yield. The number of grain spike-1 and thousand-grain weight was significantly increased in all the treatments of herbicides compared to control. The highest yield grain was obtained in the treatment of Buctril Super where weeds were completely wilted compared to all other treatments of herbicides. Economic Analysis showed that the benefit-cost ratio (BCR) of the treatment Buctril super was higher. Thus, Buctril super at 750 ml ha-1 proved to be the best herbicide for weed control in wheat and to achieve the maximum yield.