Growth, productivity and quality of pumpkin plants (Cucurbita maxima), in three substrates (a mixture of peat moss and perlite (50%: 50% v/v), a mixture of sand and rice husk (50%: 50% v/v) and Sand) were tested during 2015 and 2016 seasons. An economic evaluation of productivity in each tested substrates was measured. Results indicated that sand enhanced significantly both growth and productivity followed by the mixture of sand and rice husk. However, the lowest growth and productivity were obtained when using the mixture of Peat moss and perlite. The economic evaluation confirmed the value of using sand as agriculture substrate for producing pumpkin plants.