Carbonated soft drinks contain a multitude harmful substance; therefore, everyone should reduce their intake amounts. Beyond the fact that they have no nutritional value, these drinks can lead to long-term health problems. The present study estimated the effects of cola, orange, colorless and low calorie carbonated drinks, sucrose 10% and fructose 10% solutions on some biochemical blood parameters of experimental rats such as (triglycerides, cholesterol, LDL-c, vLDL-c, HDL-c, albumin, total protein, ALP, ALT and AST activity). Complete blood picture CBC (WBC, HGB, RBC, HCT, MCV, MCH, MCHC and PLT) and immunoglobulin bodies IgG and IgM were estimated. Histopathology examination of rat livers were also, checked. A 42 male rats were used and divided into seven groups each group contain 6 rats. The first group was the control and the other tested groups from G2 to G7 were intake cola, colorless, orange, low calorie soda drink, sucrose 10% solution and fructose 10% solution respectively. Each rate was intake 2.5 ml w/v twice daily for 60 days by using stomach tube. The resulted data showed that there were significantly differences (P< 0.05) among all tested groups in blood parameters and blood picture in comparing with control group. Histopathology estimation, also, showed some effects on liver. It could be concluded that soda drinks had harmful effects on biochemical blood parameters and blood picture of the tested rats. The highest effects were in cola and low calories. The consumption for a long time different types of carbonated drinks might be contributing to the high prevalence of liver disease and may lead to a wide range of health problems.