In the two successive growing seasons, 2017 and 2018, the efficacy of newer chemistry insecticide,  Avaunt® (Indoxacarb) and a commercial bio-insecticide, Protecto® ( B a cillu s t h u rin g ein sis kurstaki) was evaluated in the field for management of Cotton leafworm, Spodoptera littoralis Boisd. in Egypt. The tested compounds were applied at the recommended dose proposed by Agricultural Pesticide Committee (APC). Sugar beet was cultivated at Talaat-El Agamy Farm, Shenno country, Kafr El-Sheikh Governorate. The sugar beet variety (Karam) was cultivated by the end of September during the two seasons in an area of about 1\100 fed. The field evaluation revealed that Avaunt® significantly reduced the larval population of S. littoralis compared to the untreated area. Protecto® caused a significant reduction in insect infestation up to five days post treatment. Both Avaunt® and Protecto® can be used effectively by farmers as a component of integrated management of cotton leafworm in Egypt.