Background: Because of the physiological changes and a resulting immune-compromised state that render postpartum women more susceptible to COVID-19. Aim: is to assess the levels of postpartum women's knowledge, attitudes and self-protective measures regarding COVID 19. Methods: Descriptive cross sectional study design at Sohag University Hospital on 350 postpartum women by using an interviewing questionnaire, assess postpartum women`s knowledge and Likert scale to assess attitudes toward COVID -19 infection& prevention. Results: About 52.6% of the studied women had a poor knowledge about COVID-19, about 18.6% of the studied women had a highly satisfactory practices regarding COVID-19 and about 64.6% of the studied women had a positive attitude regarding COVID-19. Conclusion: More than half of the women in the study have poor knowledge, close to a quarter have unsatisfactory practices and more than a third have a negative attitude on COVID-19. Recommendations: Promotion of intensive health educational program regarding prevention of COVID19 on at all levels.