Particularly in the current healthcare market, talent management is a comprehensive strategy and a source of competitive advantage. In order to increase organizational entrepreneurship and creativity and thereby create a high-performance, sustainable organization that achieves its strategic and operational objectives and goals, talent management is a crucial component of human resource management. It includes integrated practices for attracting, developing, motivating, and retaining productive, engaged nurses. Aim: To explore the influence of talent management on organizational entrepreneurship and nurses' creativity at Oncology Center Mansoura University (OCMU). Design: A descriptive correlational design was utilized. Subjects: All nurses working in Oncology Center Mansoura University (n=102). Tools: Three tools were used for data collection, namely; Talent Management Scale (TMS), Corporate Entrepreneurship Assessment Instrument (CEAI), and Employee Creativity Scale (ECS). Results: There was a statistically significant positive correlation between talent management practices (TMP) and organizational entrepreneurship. All dimensions of talent management had significant relationship with all dimensions of organizational entrepreneurship. Also, a statistically significant positive correlation was found between talent management practices and nurses' creativity. In addition to that, about half of the studied nurses had high creativity level. Conclusion: TMP have a significant influence on increasing organizational entrepreneurship and nurses' creativity. Recommendation: Hospital administrators should implement talent management practices including attracting, selecting, developing and retaining high-potential nurses. Creating a nurturing environment that fosters nurses' independence and willingness to take risks, which fosters entrepreneurship and nurses' creativity.