Background: healthy Bed bath is required to avoid skin complications among critical illness patients in the intensive care unit. Aim of the study: This study aimed to evaluate the effect of implementing healthy bed bath to reduce Skin complication among Critically Ill Patients. Research design: The present study is a quasi-experimental research design was conducted at three medical care units (critical care, general and intensive trauma care units) at Assiut University Hospital. Method: Data collected through a period of six months, from first of December 2020 to the end of May 2021on 60 patients who were selected by convenience sampling method and assigned into two equal groups Control group received traditional by bed bath using one towel and water with soap every day, while study group received healthy bed bath by using six wipes and water with chlorhexidine every 12 hours. Two tools were used in this study, Tool Ⅰ: General assessment sheet, Tool II: Patients' outcomes evaluation sheet. Results: The current study showed that the control group had longer ICU stay and higher skin complications on the study group (25.67±13.49 versus 17.7±59) and lower Braden score compared to the study group (P<0.001). Conclusion: Skin nursing care by healthy bed bath using antimicrobial agents every 12 hours is extremely effective in reducing skin complications among ICU patients. Recommendations: Update the critical care nurses knowledge about different routes of skin care.