The postnatal period marks an important time of adaptation, changes that occur during postpartum period strongly impact on women's lives that can be overcomed by nursing education that focused on the improvement of women's knowledge, self-care. This study aimed to evaluate the women's knowledge levels about postpartum period and its minor discomfort and improve their self-care. Research design: qusiexpermental research design was utilized in this study. Sample: The study carried out on (200) immediate postnatal mother, who had normal labour, ages ranged from (20-35) years old. Setting: The study was conducted in Women's Health Hospital (emergency unit) at Assiut University Hospital. Tools: Two tools were used: woman assessment sheet, pre-post knowledge levels and SelfCare questionnaire. Results: There were a statistical significant difference between knowledge level, self-care pre and post-test after implementing nursing education (P=0.001). Conclusion: there was significant improvement in women's knowledge and reported self-care practice regarding postpartum minor discomfort after health education. Recommendation: Educate mothers in late pregnancy about physiologyical changes and postpartum minor discomfort and how to deal with this discomfort