Background: Diabetic peripheral neuropathy (DPN) is a chronic, major complication of diabetes, assessment of patients' educational needs plays important role in inhibiting and decreasing the risk of disabilities and lower limp amputation among these patients. Aim: Assess educational needs for prevention of peripheral neuropathy deterioration in diabetic patients. Research question: What are the educational needs for prevention of peripheral neuropath deterioration in diabetic patients? Research design: A descriptive research design had been utilized to conduct this study. Subjects: seventy adult, type I D.M, stage II DPN enrolled in this study. Setting: This study was conducted in the vascular surgery department at Main Assiut University Hospital. Two tools were utilized for data collections: Tool I patient assessment sheet, and Tool II nursing educational needs questionnaire sheet. Results: Shows that the mean age of studied patients was 55.20±8.00. 62% had sever degree of DPN in their right side 55% had moderate degree of DPN in their left side. Regarding educational needs about prevention of DPN deterioration; 52.9% had high level of knowledge; 25.7% had moderate level, and 21.4% had low level of knowledge. Conclusion: It was concluded that more than half of patient had adequate level of knowledge, while the second half of patients had inadequate level of knowledge regarding their educational needs about DPN deterioration prevention. Recommendation: A multidisciplinary diabetic neuropathy education should be accessible for prevention of DPN stages deterioration.