Background: Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder marked by problems paying attention, excessive activity, and impulsivity. In addition, empowerment is a metric that used to improve autonomy and self-determination through participation and support. As a result, mothers' engagement and education level was a crucial factor in ensuring that children with ADHD have a high quality of life. Aim was to empower and maintain quality of life of mothers who have primary school children with attention deficit hyperactivity disorder. Research design: A quasi-experimental research was used in this study. Setting: The study was carried out in El Shaheed and Al Fath primary schools at Minia City. Sample: A purposive sample included 50 mothers of children with ADHD. Tools of data collection: Three instruments were utilized to gather data: an interview questionnaire sheet, an empowerment scale, and the third: World Health Organization Quality of LifeBrief (WHOQOL-BREF). Results: The current study revealed a considerable increase in mothers' empowerment and a high quality of life in the post-test period. Conclusion: There was a significant improvement in mothers' awareness of ADHD after the training was implemented. In the pretest, mothers' empowerment was low, but it improved in the post-test, with a statistically significant difference. The quality of mothers' life in the pre-test was low and in the post-test became high. Recommendations: Future researches are required to develop and refine interventions through applying social empowerment and maintain quality of life.