Mothers caring for children with disabilities often experience parental stress, than mothers of children without disabilities due to the range of challenges they face. Aim: explore the relationship between parenting stress and social support among mothers of children with different disabilities. Subjects & Method: A descriptive correlational design was utilized. A convenient sample composed 100 of mothers of disabled children who agreed to participate in this study. Data collection tool include: socio-demographic characteristics sheet, parental stress scale, and multidimensional scale of perceived social support. Results: The majority of mothers have moderate and sever levels of parental stress respectively and majority of mothers have lower level of social support. Also, there is a negative and highly statistically significant correlation between total parental stress and social support scores among mothers of handicap children. Conclusion: Mothers of children with different disabilities experiences higher level of stress and lower level of social support. Recommendations: Design continuing health education, training programs, and stress management techniques for mothers who have children with disabilities to face stress and coping with it.