Background: Mindfulness-Based Interventions (MBI) have revealed efficacies in lowering psychological problems including depression and anxiety in a variety of clinical settings, including psychosis. Aim: The current study aimed to assess the effect of MBI on recent-onset psychosis for patients with schizophrenia. Methods: A randomized control trial research design recruited 69 patients with schizophrenia and randomly assigned them to a MBI group (35 patients) who received seven 90-minutes weekly group sessions and to a treatment-as-usual (TAU) group (34 patients). After informed consent, all patients were assessed using the Positive and Negative Syndrome Scale (PANSS), the Recovery Assessment Scale-Domains and Stages (RAS-DS), and the Five Facet Mindfulness Questionnaire (FFMQ) at baseline and post-intervention. Results: No significant difference was found between MBI group and TAU group regarding sociodemographic and clinical characteristics, studied domains and total scores of studied variables before the intervention. After application of the intervention, there was a significant difference between TAU group and MBI group in domains of positive psychosis symptoms, negative psychosis symptoms general psychopathology, PANSS total score (Z= 2.06, 3.11, 2.16 and 2.46 respectively). Besides, there was a significant difference between TAU group and MBI group regarding RAS-DS total score and FFMQ total score (Z= 4.19 and 4.78 respectively). Conclusion: This study preliminarily recognized prompt and transient benefits of MBI as a third-wave intervention on recent-onset psychosis for patients with schizophrenia. These types of intervention are recommended for nurses as a complementary treatment for positive and negative symptoms and enhancing recovery among schizophrenia patients