Background: Enhancing secondary school students is important and attracts a role in the future nursing generation. Aim of the study: To assess the perception of secondary school students regarding career choices who enrolled in the faculty of nursing. Research design: A descriptive correlational research design. Sample: a convenient sample (All available) of Secondary School students enrolled in the first-year faculty of nursing with total numbered 455 students during data collection periods. Setting: this study conducted in the faculty of nursing, Minia University. Data collection tool: Perceptions of a professional nursing and career choices questionnaire was used. Results: nearly one-third said the main reason for enrollment is the desire to help, and the majority of them have a proud feeling about nursing as a Profession. Most of the studied students had a positive perception of the nursing profession, while the minority had a negative perception. Conclusion: Most Secondary School Students who enrolled in the faculty of nursing had positive career choices and no relation between demographic characteristics of the studied students with perception and demographic characteristics except the feeling of nurses student about nursing as a professional Recommendations: investigate secondary students' perspectives in a different region of Egypt and recruiting needs to design in light of evidence that family members' perception of nursing impact the professional decision-making of teenagers.