Background: Adequate understanding and precautionary behaviors are of vital importance to contain the spread of coronavirus disease 2019. Aim: To assess knowledge, attitude and practices of primary schools' teachers regarding coronavirus disease 2019. Methods: Descriptive research design. Settings: Primary schools included 400 teachers. Tools: Tool (I) part (1): Personal data, part (2): Teacher's knowledge. Tool (II): Teachers' attitude toward coronavirus disease2019 and Tool (III): Observational checklist. Results: Illustrated that 70.5% of teachers were had poor score of knowledge, 57.5% had negative attitude toward Coronavirus disease 2019 and 81.25% of them were had unsatisfactory practices. There was statistical significant difference between age, years of experience and place of residence of teachers with the total score of knowledge, there was statistical significant difference between years of experience and residence with total score of attitude. Also there was statistical significant difference between teachers' age, educational level and years of experience with the total score of practices. Conclusion: Most of the studied teachers had poor score of knowledge and negative attitude toward coronavirus disease 2019 while the majority of them had unsatisfactory practices. Recommendations: Educational and training programs should target schools' teachers about coronavirus disease 2019.