Background: Pregnant women are a vulnerable group, so improving knowledge, perception, attitude, and practises regarding COVID-19 are key elements that ensure pregnant women's health and safety. The aims of the study are to assess the knowledge, perceptions, attitude, and practices for pregnant women about the coronavirus (COVID-19) and evaluate the effect of health educational intervention on pregnant women's knowledge, perceptions, attitudes, and self-protective measures (practices) toward the prevention of corona virus. Setting: The study was conducted at an antenatal outpatient clinic and an emergency clinic at Woman's Health Hospital in Assiut City. Methods: A purposive sample of 277 pregnant women was included in the study. A quasi-experimental research design was used. Tools: five tools were used, including a structured interview questionnaire, knowledge, perception, attitude, and self-protective scale. Results: There are statistically significant differences between pre and posttest regarding total knowledge, perception, practices, and attitudes of pregnant women about Covid-19 after the implementation of the educational program at p-value 0.001**.Conclusion: Educational program was significantly improving pregnant women's knowledge, perception, attitude, and practice regarding prevention of COVID 19. Recommendation: Pregnant women should be given continuous education to raise their awareness about the preventive measures for COVID-19 infection.