Gastroesophageal reflux disease (GERD) is reported in up to 80% of pregnancies. Aim of the study: To evaluate the impact of educational guidelines on improving knowledge, lifestyle and quality of life for pregnant women with GERD. Methods: A Quasi-experimental research design was used to achieve the aim of the study. Setting: The research was carried out at out-patient antenatal clinics in Minia University Hospital for Obstetrics and Pediatrics (MUHOP). Sampling: A purposive sample of 80 pregnant women with GERD was recruited. Tools: Four tools were utilized for data collection, Tool (1): socio-demographic data, obstetric history and history of GERD, Tool (2) knowledge assessment tool about GERD, Tool (3) lifestyle assessment tool regarding GERD, and Tool (4) Gastroesophageal reflux disease health-related quality of life assessment tool (GERD-HRQL). Results: The current study revealed that 72.5 % of the studied women had poor knowledge about GERD in pretest which decreased to 6.3% in posttest. Additionally, it revealed that 76.3 % of studied women had unhealthy lifestyle regarding GERD in pretest reduced to 8.8 % in posttest. Furthermore, it revealed that 72.5 % of studied women had poor QOL toward GERD in pretest diminished to 18.8 % of in posttest. Also, there were a positive correlation between studied women's knowledge, Lifestyle and QOL in pretest and posttest with statistically significant differences. Conclusion: Application of educational guidelines have a good impact on improving knowledge, lifestyle and quality of life of pregnant women suffer from GERD. Recommendations: Provision of in-service educational program and ongoing supervision in rural regions to increase pregnant women's awareness of GERD and the importance of lifestyle adjustments.